We study the neural mechanisms governing behavior and physiology. Using cutting-edge approaches, we are working to understand the molecular, cellular, and circuit mechanisms through which the brain regulates feeding and cardiovascular homeostasis. We are also developing novel technologies to better understand how the brain effects changes in behavior and physiology. We have largely focused our research efforts on the brainstem cell types regulating food intake and energy expenditure. More recently, we have also begun investigating neuro-cardiac interactions through the lens of the peripheral nervous system. We believe that studying these distinct systems may elucidate novel biological mechanisms underlying organismal homeostasis, and may change how we diagnose and treat maladaptive states that arise from neuronal malfunction, such as obesity, cardiovascular disease, and type 2 diabetes.

Molecules

We are working to characterize the molecular composition of neuronal cell types across the brain and body that are key for behavior and physiology, using ensemble and single-cell profiling methodologies.

Cells

Using functional approaches, such as in vivo calcium imaging and optogenetics, we are probing the function of discrete cell types throughout the brain and body.

Circuits

Through the development and application of new viral approaches, we are working to identify polysynaptic circuits that link neurons to diverse peripheral targets.

Behavior & Physiology

Our lab is most interested in characterizing the neuronal cell types regulating behavioral and physiologic processes responsible for maintaining energy balance and cardiovascular homeostasis.